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peroxisome proliferator-activated receptor alpha

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Thre...

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Data Correlations | 1,062 studies

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Tissues category icon Normal tissues
Score Help
Cortex of kidney 100 100
Medulla of kidney 93 93
Quadriceps femoris 85 85
Nipple 79 79
Epidermis 78 78
Subdivision of nucle… 78 78
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Compounds category icon Compounds
Score Help
Fenofibrate 100 100
Zinc03995968 100 100
Tinidazole 95 95
Proglumide 94 94
Capsaicin 94 94
Ferulic Acid 94 94
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Diseases category icon Diseases
Score Help
Familial hyperlipopr… 100 100
General adaptation s… 57 57
Bordetella 49 49
Metabolic syndrome X 47 47
Disuse atrophy 46 46
Effects of low tempe… 42 42
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • OMIM - Hyperlipidemia

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving PPARA.

View All Author iconAuthors
  • Bart Staels
  • Daniel P Kelly
  • Ronald M Evans
  • Clay F Semenkovich
  • Walter Wahli
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Eli Lilly and Company
  • Assistance Publique - Hôpitaux de Paris
  • Baskent University
  • Vanderbilt University
  • Dana-Farber Cancer Institute
View All Affiliations icon Organizations
  • Washington University School of Medicine
  • University of California
  • University of Lausanne
  • Vanderbilt University Medical Center
  • University of Pennsylvania School of Medicine

Clinical Trials | 104 trials

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