NextBio

Help

peroxisome proliferator-activated receptor alpha

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Thre...

View Complete Description



Data Correlations | 1,040 studies

Help for Data Correlations View All
Tissues category icon Normal tissues
Score Help
Cortex of kidn… 100 100
Medulla of kid… 94 94
Quadriceps fem… 86 86
Duodenum 81 81
Nipple 81 81
Epidermis 80 80
View Top Normal tissues
Compounds category icon Compounds
Score Help
Fenofibrate 100 100
Zinc03995968 100 100
Tinidazole 96 96
Proglumide 94 94
Capsaicin 94 94
Ferulic Acid 94 94
View Top Compounds
Diseases category icon Diseases
Score Help
Familial hyper… 100 100
General adapta… 57 57
Metabolic synd… 53 53
Bordetella 50 50
Social environ… 47 47
Disuse atrophy 47 47
View Top Diseases

Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • OMIM - Hyperlipidemia

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving PPARA.

View All Author iconAuthors
  • Ronald M Evans
  • Clay F Semenkovich
  • Naoto Kubota
  • Takashi Kadowaki
  • Thomas P Burris
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Eli Lilly and Company
  • Assistance Publique - Hôpitaux de Paris
  • Baskent University
  • Vanderbilt University
  • Dana-Farber Cancer Institute
View All Affiliations icon Organizations
  • University of Tokyo
  • Howard Hughes Medical Institute
  • Washington University School of Medicine
  • University of Virginia Health System
  • University of California

Clinical Trials | 104 trials

Help for Clinical Trials View All

Community

Help for Community
NextBio Users

  • No NextBio users were found for “PPARA”.
    Complete your user profile with your interests, if you want others to find you within the NextBio community.

View All NextBio Groups | 1 group

© 2009 NextBio