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peroxisome proliferator-activated receptor alpha
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Thre...
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| Medulla of kidney |
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| Quadriceps femoris |
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| Nipple |
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| Zinc03995968 |
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| Tinidazole |
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| Proglumide |
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| Capsaicin |
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| Ferulic Acid |
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Authors: Manu V Chakravarthy, Irfan J Lodhi, Li Yin, Raghu R V Malapaka, H Eric Xu, John Turk, Clay F Semenkovich
Cell 2009 Aug 7Authors: Keisuke Tateishi, Yuki Okada, Eric M Kallin, Yi Zhang
Nature 2009 Apr 9Thought leaders and organizations working on research involving PPARA.
conditions: Dyslipidemia
interventions: PPAR alpha ; placebo
conditions: Mild Hypertension
interventions: PPAR alpha ; Hydrochlorothiazide ; Placebo