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phospholipase A2, group IB (pancreas)

Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM]

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Data Correlations | 706 studies

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Tissues category icon Normal tissues
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Stomach 100 100
Set of pancreatic is… 99 99
Pancreas 94 94
Small intestine 90 90
Duodenum 84 84
Oocyte 84 84
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Compounds category icon Compounds
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Carbon-14c Dioxide 100 100
Gelatine 97 97
Follicle Stimulating… 97 97
Carbenoxolone 97 97
Linalyl Pyrophosphat… 96 96
Chromium(3 ) 3-pyrid… 95 95
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Diseases category icon Diseases
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Helicobacter-associa… 100 100
Intestinal metaplasi… 96 96
Adrenal carcinoma 75 75
Helicobacter pylori … 74 74
Adenocarcinoma of lu… 74 74
Large cell carcinoma… 68 68
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Individual Studies

  • Normal tissues transcriptome_Hs: Relative gene expression

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Here, we have generated and analyzed gene expression from a set of samples spanning a broad range of biological conditions. Specifically, we profiled gene expression from 91 human samples across a diverse array of tissues, organs, and cell lines.

    Authors: Su AI, Cooke MP, Ching KA et al.

    Organization: Genomics Institute of the Novartis Resea…
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Associated Researchers

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Thought leaders and organizations working on research involving PLA2G1B.

View All Author iconAuthors
  • Michael H Gelb
  • John E Burke
  • Andrew Zalewski
  • Edward A Dennis
  • Gérard Lambeau
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
  • GlaxoSmithKline
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • National Taiwan University Hospital
  • CAMC Health System
View All Affiliations icon Organizations
  • University of California
  • Hospital of the University of Pennsylvania
  • University of Delaware
  • California Institute of Technology
  • University of Michigan

Clinical Trials | 24 trials

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Community

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