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pirin (iron-binding nuclear protein)

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq]

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Data Correlations | 1,113 studies

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Tissues category icon Normal tissues
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Mucosa of pharynx 100 100
Bronchus 94 94
Esophagus 93 93
Inferior ganglion of… 91 91
Mucosa of mouth 89 89
Penis 89 89
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Compounds category icon Compounds
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Etacrynic Acid 100 100
Masoprocol 90 90
Dichloroisothiocyana… 81 81
Deferasirox 80 80
Arsenic Trioxide 77 77
Bovinic Acid 77 77
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Diseases category icon Diseases
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Anomaly of chromosom… 100 100
Effects of low tempe… 98 98
Squamous cell carcin… 96 96
Complication of tran… 95 95
Prostatic hyperplasi… 95 95
Triploidy 93 93
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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…

  • Rat cardiomyocytes treated with quercetin

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Cardiomyocytes from the ventricles of 2–4 day old Wistar rats treated with 30uM quercetin for 6,12, or 24 hours.

    Authors: Angeloni Cristina, Leoncini Emanuela, Hrelia Silvana

    Organization: University of Bologna Biochemistry Nutri…
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Associated Researchers

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Thought leaders and organizations working on research involving PIR.

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  • Toshiyuki Takai
  • Jean Langhorne
  • William Jarra
  • Jannik Fonager
  • Deirdre Cunningham
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  • Shanghai Changzheng Hospital
  • University of Pittsburgh
  • Lindner Center of HOPE
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  • Tohoku University
  • National Institute for Medical Research
  • Universitat de les Illes Balears
  • University of Wisconsin
  • Institut Pasteur

Clinical Trials | 4 trials

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Community

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View All NextBio Users | 2 people
  • Waleed Ali Hasan Waleed Ali  Hasan

    Ass. Professor

    Royal College of Surgeons

  • Khader Shameer Khader  Shameer

    PhD Student in Prof. R. Sowdhamini's Computational Biology Lab

    National Centre for Biological Sciences - Tata Institute of Fundamental Research

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