PIK3CA - NextBio

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Search Term: PIK3CA (gene)

Overview

phosphoinositide-3-kinase, catalytic, alpha polypeptide

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq]

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Data Correlations | 1,395 studies

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Normal tissues

Score

Synovial membrane of…

100

Adrenal gland

Pericardium

Vagina

Small intestine

Caudate nucleus

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Compounds

Score

Cinnarizine

100

Praziquantel

Tris

Methylolacrylamide

Methylene Chloride

7alpha-hydroxytestos…

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Diseases

Score

Gastric cancer

100

Non-small cell lung …

Malignant glioma of …

cancer of female gen…

Cancer of intestine

Liver carcinoma

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Individual Studies
Cancer census - gene mutations in cancer and other diseases score: 100 \| Homo sapiens \| Mutations/Phenotypic The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al. Organization: Cancer Genome Project, Human Genome Anal…	OMIM - Malignant neoplasms score: 100 \| Homo sapiens \| Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data

Individual Studies

Cancer census - gene mutations in cancer and other diseases

score: 100 | Homo sapiens | Mutations/Phenotypic

The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

Organization: Cancer Genome Project, Human Genome Anal…

OMIM - Malignant neoplasms

score: 100 | Homo sapiens | Mutations/Phenotypic

This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

Source: NextBio Library/Mutation and Phenotypic data