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programmed cell death 1

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq]

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Data Correlations | 521 studies

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Tissues category icon Normal tissues
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Salivary gland 100 100
Thyroid gland 95 95
Mesenteric lymph nod… 94 94
Ganglion of cranial … 92 92
Caudate nucleus 92 92
Set of pancreatic is… 91 91
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Compounds category icon Compounds
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Pregnant Mare Serum … 100 100
Choriogonadotropin 90 90
Phenformine 89 89
Hydraztinine 86 86
Paeonol 86 86
Peoniflorin 86 86
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Diseases category icon Diseases
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Systemic lupus eryth… 100 100
Lymphocytic choriome… 99 99
Glomerulonephritis 91 91
Rhinovirus infection 79 79
Diabetes mellitus ty… 77 77
Neoplasm of thymus 77 77
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Individual Studies

  • Engagement of TCR with antibodies

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Comparison of gene expression changes using OVA-specific TCR (OT-I) TAP-/- mouse CD4+CD8+ thymocytes following engagement of TCR with anti-Vα or Vβ antibodies.

    Authors: Niederberger Nathalie, Buehler K Lukas, Ampudia Jeanette et al.

    Organization: The Scripps Research Institute Immunolog…

  • Intragraft gene expression associated with induction of tolerance

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Xenotransplantation holds the promise of providing an unlimited supply of donor organs for terminal patients with organ failure. The gal carbohydrate results in rejection of wild type pig grafts, however, chimerism established by expression of the GalT gene prior to transplantation in GalT knockout …

    Authors: Doki Tomoko, Kearns-Jonker Mary

    Organization: Childrens Hospital Los Angeles Cardiotho…
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Associated Researchers

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Thought leaders and organizations working on research involving PDCD1.

View All Author iconAuthors
  • Gordon J Freeman
  • Tasuku Honjo
  • Taku Okazaki
  • E John Wherry
  • Arlene H Sharpe
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Ernst Moritz Arndt University of Greifswald
View All Affiliations icon Organizations
  • Kyoto University
  • Harvard Medical School and Brigham and Women's Hospital
  • Emory University School of Medicine
  • University of California
  • University of Pennsylvania

Clinical Trials | 1 trial

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News | 2 stories

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Community

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