PCSK9 - NextBio

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Search Term: PCSK9 (gene)

Overview

proprotein convertase subtilisin/kexin type 9

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq]

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Data Correlations | 547 studies

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Normal tissues

Score

Cecum

100

Hemisphere of cerebe…

100

Pericardium

Set of fingers

Pylorus

Synovial membrane of…

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Compounds

Score

Cephaloridine

100

Alpha-aminoisocaproi…

Otoline

Bovinic Acid

Cddo-im

Dimethyl Sulfoxide

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Diseases

Score

Hypercholesterolemia

100

Hamman-Rich syndrome

Accelerated phase ch…

Infectious colitis

Acquired absent test…

Not getting enough s…

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Individual Studies
OMIM - Hyperlipidemia score: 100 \| Homo sapiens \| Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data	Single or combinations of deletions of Irs1, Irs2, and Foxo1 in the liver of fasted or fed mice score: 100 \| Mus musculus \| RNA Expression The effect of liver specific deletion of the insulin receptor substrate-1 (Irs1) and/or Irs2 upon gene expression in the fasted and fed liver of mice, and the effect of liver specific Foxo1 deletion in the Irs1 and Irs2 knockout liver during fasting and feeding was investigated. Source: NextBio Library/Metabolic disorders and Obesity

Individual Studies

OMIM - Hyperlipidemia

score: 100 | Homo sapiens | Mutations/Phenotypic

This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

Source: NextBio Library/Mutation and Phenotypic data

Single or combinations of deletions of Irs1, Irs2, and Foxo1 in the liver of fasted or fed mice

score: 100 | Mus musculus | RNA Expression

The effect of liver specific deletion of the insulin receptor substrate-1 (Irs1) and/or Irs2 upon gene expression in the fasted and fed liver of mice, and the effect of liver specific Foxo1 deletion in the Irs1 and Irs2 knockout liver during fasting and feeding was investigated.

Source: NextBio Library/Metabolic disorders and Obesity