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p21 protein (Cdc42/Rac)-activated kinase 4

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isofor...

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Data Correlations | 915 studies

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Tissues category icon Normal tissues
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Salivary gland 100 100
Zygote 98 98
Epidermis 96 96
Cecum 90 90
Viscerocranial mucos… 89 89
Set of fingers 88 88
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Compounds category icon Compounds
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N-butyl-2-[3-(3-chlo… 100 100
Sulfamethizole 64 64
Orphenadrine 62 62
Zinc00129343 59 59
Cefamandole 59 59
Fullerenol 58 58
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Diseases category icon Diseases
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Systemic onset juven… 100 100
Infection by Candida… 99 99
Transitional cell ca… 98 98
Chronic granulomatou… 97 97
Viral cardiovascular… 91 91
Adenocarcinoma of pr… 90 90
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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…

  • HOXA3 expression in wound tissue

    score: 9898 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Gene expression in unwounded skin, wounded skin treated with control plasmid, wounded skin treated with HOXA3.

    Source: NextBio Library/Injury & Inflammation
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Associated Researchers

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Thought leaders and organizations working on research involving PAK4.

View All Author iconAuthors
  • Audrey Minden
  • Tanya Nekrasova
  • Stefan Knapp
  • Xiaofan Li
  • George E Davis
View All Affiliations icon Organizations
  • Columbia University
  • State University of New Jersey
  • University of Oxford
  • King's College London
  • University of Rochester Medical Center

Clinical Trials | 1 trial

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Community

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