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purinergic receptor P2X, ligand-gated ion channel, 7
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Inferior ganglion of… |
100
|
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| Corpus callosum |
85
|
||
| Globus pallidus |
81
|
||
| Substantia nigra |
79
|
||
| Ventral tegmental ar… |
76
|
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| Subthalamic nucleus |
76
|
Compounds
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|
||
|---|---|---|---|
| Furaltadone |
100
|
||
| Lidocaine |
100
|
||
| Staphylococcal Enter… |
91
|
||
| Cerivastatin |
87
|
||
| Thymoglobulin |
85
|
||
| Phytohemagglutinin |
83
|
Diseases
|
|
||
|---|---|---|---|
| Leukemia |
100
|
||
| Parkinson disease |
100
|
||
| Hypoxia |
99
|
||
| Zoonotic bacterial d… |
99
|
||
| Astrocytoma |
99
|
||
| Metastasis from mali… |
97
|
 Individual Studies |
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|---|---|
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Rattus norvegicus
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RNA Expression
Mus musculus
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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Authors: François Ghiringhelli, Lionel Apetoh, Antoine Tesniere, Laetitia Aymeric, Yuting Ma, Carla Ortiz, Karim Vermaelen, Theocharis Panaretakis, Grégoire Mignot, Evelyn Ullrich,…
Nature medicine 2009 Oct -
P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.
Authors: Susanne Lucae, Daria Salyakina, Nicholas Barden, Mario Harvey, Bernard Gagné, Michel Labbé, Elisabeth B Binder, Manfred Uhr, Marcelo Paez-Pereda, Inge Sillaber,…
Human molecular genetics 2006 Aug 15
Thought leaders and organizations working on research involving P2RX7.
- GlaxoSmithKline
- Maastricht University Medical Center
- Abbott Laboratories
- Max Planck Institute of Psychiatry
- Universidad del País Vasco
- University of Sydney
- Institut National de la Santé et de la Recherche Médicale
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Cohort Study on Associations Between Purinergic Receptor SNPs and Osteoporosis Risk
conditions: Osteoporosis
interventions: none
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First Time in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and the Effect of Food of Single Assending Doses of GSK1482160.
conditions: Pain
interventions: GSK1482160 or placebo
