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O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct iso...

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Data Correlations | 2,015 studies

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Tissues category icon Normal tissues
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Superior vena cava 100 100
Subdivision of nucle… 94 94
Fundus of stomach 94 94
Pylorus 92 92
Pericardium 91 91
Lateral nuclear grou… 90 90
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Compounds category icon Compounds
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Magnesium Valproate 100 100
Morphine 100 100
Naaxia 93 93
Olive Oil (tn) 93 93
Bromovalerylurea 90 90
Cilengitide 88 88
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Diseases category icon Diseases
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Chagas' disease 100 100
Anthrax 90 90
Chronic progressive … 86 86
Crush injury, multip… 84 84
IgA myeloma 84 84
Septic enteritis 82 82
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Individual Studies

  • Early Response to Trypanosoma cruzi Infection Involves Minimal Modulation of Host Cell

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell lysosomes. To determine the consequences of T. cruzi invasion on host cell gene expression, high density microarrays con…

    Authors: Burleigh Barbara

    Organization: Stanford Microarray Database (SMD) Stanf…
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Associated Researchers

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Thought leaders and organizations working on research involving OGT.

View All Author iconAuthors
  • Gerald W Hart
  • Stephen Marshall
  • Ryo Okuyama
  • Gladys A Ngoh
  • Jeffrey E Kudlow
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Actelion
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • Laboratoires CARILENE
  • National Eye Institute (NEI)
  • Lady Hardinge Medical College
View All Affiliations icon Organizations
  • Harvard Medical School
  • University of Dundee
  • University of Alabama - Birmingham
  • National Institutes of Health
  • University of Louisville School of Medicine

Clinical Trials | 8 trials

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Community

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