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neurotrophin 4
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Set of fingers |
100
|
||
| Epidermis |
97
|
||
| Preoptic area |
88
|
||
| Femur |
86
|
||
| Cecum |
85
|
||
| Tongue |
83
|
Compounds
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|
||
|---|---|---|---|
| CID 12623 |
100
|
||
| Phenothiazine |
69
|
||
| Carmustine |
65
|
||
| Cycloheximide |
59
|
||
| Acodazole |
59
|
||
| Diclofenac |
56
|
 Individual Studies |
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|---|---|
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Rattus norvegicus
|
RNA Expression
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Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma.
Authors: Francesca Pasutto, Tomoya Matsumoto, Christian Y Mardin, Heinrich Sticht, Johann H Brandstätter, Karin Michels-Rautenstrauss, Nicole Weisschuh, Eugen Gramer, Wishal D Ramdas, Leonieke M E van Koolwijk,…
American journal of human genetics 2009 Oct -
No Evidence of Association of Heterozygous NTF4 Mutations in Patients with Primary Open-Angle Glaucoma.
Authors: Yutao Liu, Wenjing Liu, Kristy Crooks, Silke Schmidt, R Rand Allingham, Michael A Hauser
American journal of human genetics 2010 Mar 12
Thought leaders and organizations working on research involving NTF5.
- Duke University Medical Center
- Whitehead Institute for Biomedical Research
- Institute of Neuroscience
- University Erlangen-Nuremberg
- Duke University Eye Center
