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nerve growth factor (beta polypeptide)

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq]

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Data Correlations | 819 studies

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Tissues category icon Normal tissues
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Adrenal gland 100 100
Core region of nucle… 98 98
Pericardium 98 98
Segment of venous tr… 96 96
Uterus 95 95
Ciliary ganglion 94 94
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Compounds category icon Compounds
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Nchembio790-comp36 100 100
Taxotere 92 92
Parthenolide 92 92
Triferric Doxorubici… 88 88
Matrigel 87 87
Prostaglandins F 86 86
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Diseases category icon Diseases
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Neuropathy 100 100
Cicatrization 100 100
Keloid 100 100
Monoclonal gammopath… 96 96
Helicobacter pylori … 95 95
Adenovirus infection 86 86
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Individual Studies

  • TGF-beta1 effects on normal, IPF and fibrosing alveolitis lung cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The response to a 4 hour treatment with TGFbeta (4 ng/ml) was evaluated in lung fibroblasts derived from three controls (normal periphery of resected tumor), open lung biopsies from three patients with idiopathic pulmonary fibrosis (usual interstitial pneumonia pattern on biopsy) and from three pati…

    Authors: Renzoni A Elisabetta, Abraham J David, Howat Sarah et al.

    Organization: Royal Brompton Hospital/Imperial College…
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Associated Researchers

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Thought leaders and organizations working on research involving NGF.

View All Author iconAuthors
  • William C Mobley
  • David D Ginty
  • Louis F Reichardt
  • Alun M Davies
  • Ulrich Hengst
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Ceregene
  • Pfizer
  • University of Wisconsin, Madison
  • PanGenetics UK Limited
  • The Shiley Family Trust
View All Affiliations icon Organizations
  • Johns Hopkins University School of Medicine
  • Stanford University School of Medicine
  • Cornell University
  • Institute of Biophysics
  • Stanford University

Clinical Trials | 18 trials

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Community

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