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nuclear factor (erythroid-derived 2)-like 2

NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995 [PubMed 7868116]).[supplied by OMIM]

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Data Correlations | 1,774 studies

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Tissues category icon Normal tissues
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Esophagus 100 100
Vomeronasal organ 97 97
Viscerocranial mucos… 96 96
Penis 92 92
Stomach 90 90
Pylorus 87 87
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Compounds category icon Compounds
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Gsh 100 100
Pergamid 78 78
Thos Streptonigrin 76 76
Tetrachlorodibenzo-p… 76 76
Liposome 71 71
Clodronate 71 71
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Diseases category icon Diseases
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Traumatic hemorrhage 100 100
Hypoxic-ischemic bra… 98 98
Adenovirus infection 98 98
Heat exposure 96 96
Streptococcal infect… 94 94
Effects of heat 93 93
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Individual Studies

  • Peripheral blood mononuclear, DU145, and HCT116 cells treated with R547 CDK inhibitor

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A genomics-based approach to identify pharmacodynamic biomarkers was used for a CDK (cyclin-dependent kinase) inhibitory drug, R547 ( [4-​amino-​2-​[(1-​methylsulfonylpiperidin-​4-​yl)amino]pyrimidin-​5-​yl]-​(2,3-​difluoro-​6-​methoxyphenyl )methanone.

    Organization: Roche In Silico Sciences 340 Kingsland S…

  • Nrf2-null mice alveolar type II cells

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    We hypothesize that gene expression in the Type II cells of Nrf2+/+ and Nrf2-/- mice are divergent thus contributing the cell growth. More specifically, type II cells from Nrf2-/- mice have increased reactive oxygen species that cause the impaired cell growth. In order to test these hypotheses at th…

    Authors: Scollick CM, Machireddy N, Kleeberger SR et al.

    Organization: Bloomberg School of Public Health Enviro…
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Associated Researchers

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Thought leaders and organizations working on research involving NFE2L2.

View All Author iconAuthors
  • Masayuki Yamamoto
  • Shyam Biswal
  • Nobunao Wakabayashi
  • Zheng Sun
  • Akira Kobayashi
View All Affiliations icon Organizations
  • University of Arizona
  • Johns Hopkins Bloomberg School of Public Health
  • University of Dundee
  • Johns Hopkins University
  • National Cancer Center Research Institute

Community

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