The CCAAT-binding factor (CBF) is a mammalian transcription factor that binds to a CCAAT motif in the promoters of a wide variety of genes, including type I collagen and albumin. The factor is a heteromeric complex of A and B subunits, both of which are required for DNA-binding. The subunits can interact in the absence of DNA-binding, conserved regions in each being important in mediating this interaction.

Data Correlations | 1,183 studies

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Normal tissues	Score
B lymphoblast	100
Quadriceps femoris	99
Substantia nigra	99
Cecum	98
Subthalamic nucleus	97
Trigeminal ganglion	97

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Compounds	Score
Digoxigenin	100
Corchoroside A	98
Strophanthidin	96
Exonuclease Iii	95
Synandone	93
Alginate	92

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Diseases	Score
cancer of fallopian …	100
Neoplasm of vulva	98
Primary cutaneous di…	95
Conn syndrome	89
Chronic fatigue synd…	88
Anogenital human pap…	86

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Individual Studies
FoxM1 siRNA profiles in BT-20 breast cancer cells score: 100 | Homo sapiens |   RNA Expression BT-20 breast cancer cells were exposed to a mock transfection, GFP siRNA, or FoxM1 siRNA. Each condition was performed in triplicate, and RNA was collected after 48hrs. Authors: 15958562 Organization: Wyeth Research Cambridge MA 02140 Countr…	B cells treated with CD40, Anti-IgM, ELC, IL4, terbutaline and LPS score: 99 | Mus musculus |   RNA Expression Temporal analysis (60, 180, 360 min) of B cells treated with CD40, Anti-IgM, ELC, IL4, terbutaline and lipopolysaccharide treatment Authors: Cao Yun-Anna, Chang Mi-Sook, Lee Sun-Young et al. Organization: California Institute of Technology Biolo…

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Literature | 820 results

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• Mutant p53 gain of function: the NF-Y connection.

  Authors: Melissa J Peart, Carol Prives

  Cancer cell 2006 Sep

• Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation.

  Authors: Silvia Di Agostino, Sabrina Strano, Velia Emiliozzi, Valentina Zerbini, Marcella Mottolese, Ada Sacchi, Giovanni Blandino, Giulia Piaggio

  Cancer cell 2006 Sep

Associated Researchers

Thought leaders and organizations working on research involving NF-Y.

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• Roberto Mantovani
• Raffaella Gatta
• Velia Emiliozzi
• Sankar N Maity
• Ada Sacchi

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• Università di Milano
• Columbia University
• Istituto Regina Elena
• Università di Modena e Reggio
• Instituto de Investigaciones Biomédicas

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