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nuclear cap binding protein subunit 1, 80kDa

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq]

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Data Correlations | 750 studies

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Tissues category icon Normal tissues
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Caudate nucleus 100 100
B lymphoblast 100 100
Esophagus 98 98
Bronchus 98 98
Smooth muscle tissue 97 97
Subdivision of nucle… 97 97
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Compounds category icon Compounds
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Sirolimus 100 100
Dimethadione 96 96
Debrisoquine 95 95
Diphemanil 92 92
Banthine 89 89
Urapidil 87 87
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Diseases category icon Diseases
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Mycosis fungoides 100 100
Limited scleroderma 73 73
Squamous cell carcin… 72 72
Disease due to Papil… 72 72
Quadriplegia 70 70
Coccidiosis 70 70
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Individual Studies

  • MRC-5 Lung fibroblast cells treated with rapamycin to study alternative translational routes

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Anti-cancer drugs targeting protein synthesis are confronted by the problem that genes can exploit alternative translational routes. Polysomes were isolated from MRC-5 cells treated with rapamycin and compared to polysomes from untreated controls to investigate these routes.

    Source: NextBio Library/Pharmacology and Toxicology
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Associated Researchers

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Thought leaders and organizations working on research involving NCBP1.

View All Author iconAuthors
  • Lynne E Maquat
  • Yoon Ki Kim
  • Fabrice Lejeune
  • I W Mattaj
  • Artur Jarmolowski
View All Affiliations icon Organizations
  • University of Rochester
  • Korea University
  • Adam Mickiewicz University
  • European Molecular Biology Laboratory
  • Cornell University

Clinical Trials | 1 trial

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Community

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