Gene expression profiling and correlation with outcome in clinical trials of bortezomib in myeloma

score: 100 | Homo sapiens |   RNA Expression

Purified myeloma samples were collected prior to enrolment in clinical trials of bortezomib (PS-341) then various patient parameters were reported such as response, TTP, and survival upon treatment with bortezomib or dexamethasone.

Source: NextBio Library/Oncology

Effect of HDAC inhibitors on expression of androgen induced genes

score: 100 | Homo sapiens |   RNA Expression

LNCaP prostate cancer cells were grown in charcoal stripped, androgen deplete medium. They were then stimulated with or without 1nM R1881 and with or without two doses of HDAC inhibitors TSA, SAHA, and LBH 589. Cyclohexamide was include to block new protein synthesis. Cells were harvested 16 hours a…

Authors: Welsbie S Derek, Xu Jin, Chen Yu et al.

Organization: Memorial Sloan Kettering Cancer Center H…