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Search Term: NAPA (gene)

Overview

N-ethylmaleimide-sensitive factor attachment protein, alpha

The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP...

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Data Correlations | 1,514 studies

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Normal tissues

Score

Adrenal gland

100

Pericardium

Cecum

Set of cerebellar pe…

Mucosa of mouth

Trigeminal ganglion

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Compounds

Score

Molindone

100

Ganciclovir Sodium

Benserazide

Levocabastine

Mitomycin C

Propylene Glycol Usp

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Diseases

Score

SAIDS

100

Human immunodeficien…

Dengue fever

Acquired immunodefic…

Encephalomyelitis

Falciparum malaria

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Individual Studies
Inducible expression of PrPC in mouse skeletal muscles score: 100 \| Mus musculus \| RNA Expression Wild type (WT), PrP-null, and transgenic mice were fed food either lacking or containing 6g doxycycline (Dox)/kg food to induce PrPC expression. Skeletal muscles from the quadriceps of hind legs were removed at 0, 4, 7, 14, 30 and 60 days. Total RNA was isolated from these tissues for use in subseq… Authors: Liang Jingjing, Parchaliuk Debra, Medina Sarah et al. Organization: Public Health Agency of Canada Prion Dis…	Broad Connectivity Map (CMAP 2.0) compound database score: 100 \| Homo sapiens \| RNA Expression A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes. Authors: Lamb J Organization: Broad Institute Seven Cambridge Center C…

Individual Studies

Inducible expression of PrPC in mouse skeletal muscles

score: 100 | Mus musculus | RNA Expression

Wild type (WT), PrP-null, and transgenic mice were fed food either lacking or containing 6g doxycycline (Dox)/kg food to induce PrPC expression. Skeletal muscles from the quadriceps of hind legs were removed at 0, 4, 7, 14, 30 and 60 days. Total RNA was isolated from these tissues for use in subseq…

Authors: Liang Jingjing, Parchaliuk Debra, Medina Sarah et al.

Organization: Public Health Agency of Canada Prion Dis…

Broad Connectivity Map (CMAP 2.0) compound database

score: 100 | Homo sapiens | RNA Expression

A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

Authors: Lamb J

Organization: Broad Institute Seven Cambridge Center C…