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mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Preoptic area |
100
|
||
| Epidermis |
94
|
||
| Tongue |
93
|
||
| Cecum |
92
|
||
| Vomeronasal or… |
91
|
||
| Femur |
90
|
Compounds
|
|
||
|---|---|---|---|
| Light |
100
|
||
| 2,2-dichloroac… |
88
|
||
| Aids180489 |
85
|
||
| Chinethazonum |
83
|
||
| Aminophenazone |
80
|
||
| Alcuronium Chl… |
73
|
Diseases
|
|
||
|---|---|---|---|
| Deletion and d… |
100
|
||
| Infection due … |
93
|
||
| Metastasis fro… |
88
|
||
| Other specifie… |
86
|
||
| Infectious col… |
83
|
||
| Actinic kerato… |
83
|
 Individual Studies |
|
|---|---|
|
|
Mus musculus
|
RNA Expression
Homo sapiens
|
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Suppression of tumor growth and metastasis in Mgat5-deficient mice.
Authors: M Granovsky, J Fata, J Pawling, W J Muller, R Khokha, J W Dennis
Nature medicine 2000 Mar -
Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells.
Authors: Annick Lagana, Jacky G Goetz, Pam Cheung, Avraham Raz, James W Dennis, Ivan R Nabi
Molecular and cellular biology 2006 Apr
Thought leaders and organizations working on research involving Mgat5.
- Samuel Lunenfeld Research Institute
- Fudan University
- University of British Columbia
- Nagoya University Graduate School of Medicine
- University of Toronto
