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mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies. [provided by RefSeq]
Diseases
|
|
||
|---|---|---|---|
| Deletion and duplica… |
100
|
||
| Human anaplasmosis |
79
|
||
| Actinic keratosis |
79
|
||
| Injury of external e… |
76
|
||
| Pulmonary hypertensi… |
75
|
||
| Diabetes mellitus ty… |
74
|
Gene perturbations
|
|
||
|---|---|---|---|
| LASP1 gene |
100
|
||
| Dmel_CG10388 gene |
97
|
||
| GK gene |
95
|
||
| THRA gene |
86
|
||
| YOL081W gene |
85
|
||
| IL10 gene |
80
|
Compounds
|
|
||
|---|---|---|---|
| Light |
100
|
||
| 2,2-dichloroacetyl c… |
99
|
||
| Quinethazone |
96
|
||
| Alcuronium |
88
|
||
| Sulfacetamide |
88
|
||
| Bismuth |
88
|
 Individual Studies |
|
|---|---|
|
|
Mus musculus
|
RNA Expression
Homo sapiens
|
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MGAT5 alters the severity of multiple sclerosis.
Authors: B Brynedal, J Wojcik, F Esposito, V Debailleul, J Yaouanq, F Martinelli-Boneschi, G Edan, G Comi, J Hillert, H Abderrahim
Journal of neuroimmunology 2010 Mar 30 -
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation.
Authors: M Demetriou, M Granovsky, S Quaggin, J W Dennis
Nature 2001 Feb 8
Thought leaders and organizations working on research involving Mgat5.
- Fudan University
- Samuel Lunenfeld Research Institute
- Nagoya University Graduate School of Medicine
- University of Toronto
- University of British Columbia
