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Description: A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic RENAL FAILURE. It also tends to lower BLOOD PRESSURE and increase POTASSIUM loss.
Molecular weight: 365.835 g/mol
Molecular formula: C16H16ClN3O3S
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Data Correlations | 2 studies

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Genes category icon Genes
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SLC12A1 100 100
ANP32A 86 86
55454 86 86
PRKAR1A 85 85
ADAM9 84 84
DARS 81 81
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Biogroups category icon Biogroups
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RNA-directed DNA polymerase (revers… 100 100
Attenuation of GPCR Signaling 97 97
Diacylglycerol Signaling 97 97
Activation of cAMP-dependent Protei… 97 97
PELP1 Pathway 96 96
MTA3 Pathway 96 96
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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving Metolazone.

View All Author iconAuthors
  • Stefaan J H Soenen
  • Marcel De Cuyper
  • Ute Schütte
  • Changxiao Liu
  • Andrew J Patterson
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Mylan Pharmaceuticals
  • University of New Mexico
  • The University of North Carolina, Chapel Hill
  • Medical University of South Carolina
  • Department of Veterans Affairs
View All Affiliations icon Organizations
  • University of Oxford
  • Katholieke Universiteit Leuven, Campus Kortrijk
  • National Veterinary Institute and Swedish University of Agricultural S…
  • University of Missouri - Kansas City
  • University of Queensland

Clinical Trials | 9 trials

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