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v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq]

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Data Correlations | 1,392 studies

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Tissues category icon Normal tissues
Score Help
Fetal organ 100 100
Blastocyst 90 90
Embryo 89 89
Epidermis 88 88
Ganglion of cranial … 88 88
Globus pallidus 88 88
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Compounds category icon Compounds
Score Help
Phenylalanine Amide 100 100
Nsc618084 96 96
Actinomycin 96 96
Dapt 95 95
Thioacetamide 85 85
Oxytetracycline, Dis… 83 83
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Diseases category icon Diseases
Score Help
Microcephaly 100 100
Neuroblastoma of bra… 99 99
Retrovirus as the ca… 99 99
Neuroendocrine carci… 89 89
Papilloma of skin 86 86
Large cell carcinoma… 85 85
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Individual Studies

  • Transformed glial progenitor cells

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    The goals of this research are three-fold: (i) One is to identify genetic changes associated with tumorgenesis that interfere with the ability of transformed glial cells to differentiate. This is connected with (ii) our analysis of the regulation of differentiation in normal glial progentor cells,…

    Authors: Proschel Christoph

    Organization: NIH Neuroscience Microarray Consortium N…

  • Defining gene classes critical to cancer phenotype

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Understanding the molecular underpinnings of cancer is of critical importance to developing targeted intervention strategies.

    Authors: Land H, McMurray <a href="../home/home.nb?q=HR">HR</a>, Sampson ER et al.

    Organization: University of Rochester Medical Center B…
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Associated Researchers

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Thought leaders and organizations working on research involving MYCN.

View All Author iconAuthors
  • Hans van Bokhoven
  • William A Weiss
  • Frank Westermann
  • Glenn M Marshall
  • Arjan P M de Brouwer
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Children's Oncology Group
  • Memorial Sloan-Kettering Cancer Center
  • European Infant Neuroblastoma Study Group - 1999
  • Children's Cancer and Leukaemia Group
  • St. Jude Children's Research Hospital
View All Affiliations icon Organizations
  • Children's Hospital of Philadelphia
  • Radboud University Nijmegen Medical Centre
  • Newcastle University
  • National Cancer Institute
  • University of Pennsylvania School of Medicine

Clinical Trials | 44 trials

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Community

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