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mutY homolog (E. coli)

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

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Data Correlations | 871 studies

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Tissues category icon Normal tissues
Score Help
Caudate nucleus 100 100
Ciliary ganglion 100 100
Zygote 97 97
Pylorus 96 96
Subdivision of subst… 96 96
Thyroid gland 94 94
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Compounds category icon Compounds
Score Help
Synandone 100 100
Ergocalciferols 97 97
Nimetazepam 93 93
Etodolac 88 88
Sulfur Dioxide 85 85
Vorinostat 82 82
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Diseases category icon Diseases
Score Help
Adenoma of large int… 100 100
Gastric cancer 99 99
Cancer of intestine 98 98
General adaptation s… 68 68
Idiopathic thrombocy… 58 58
cancer of hypopharyn… 57 57
View Top Diseases

Individual Studies

  • OMIM - Neoplasms

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Cancer census - gene mutations in cancer and other diseases

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

    Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

    Organization: Cancer Genome Project, Human Genome Anal…
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Associated Researchers

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Thought leaders and organizations working on research involving MUTYH.

View All Author iconAuthors
  • Julian R Sampson
  • S Aretz
  • Frederik J Hes
  • Liliana Varesco
  • Jeremy P Cheadle
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • UCB
  • VIVUS, Inc.
  • Chinese Academy of Sciences
View All Affiliations icon Organizations
  • University of Bonn
  • Kyushu University
  • Leiden University Medical Center
  • Cardiff University
  • London Research Institute

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