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mucin 1, cell surface associated

This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternati...

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Data Correlations | 1,341 studies

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Tissues category icon Normal tissues
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Cardia of stomach 100 100
Pylorus 95 95
Fundus of stomach 91 91
Uterine tube 86 86
Bronchus 82 82
Vomeronasal organ 81 81
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Compounds category icon Compounds
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Cyclopenthiazide 100 100
Seneciphyllin 95 95
Dalzic 92 92
Trastuzumab 88 88
Clorsulon 87 87
Elaidic Acid 86 86
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Diseases category icon Diseases
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Non-Hodgkin's lympho… 100 100
Crohn's disease of i… 100 100
Mucinous cystadenoma… 98 98
Streptococcus pyogen… 98 98
Squamous cell carcin… 97 97
Non-small cell lung … 96 96
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Individual Studies

  • Non Small Cell Lung Cancer

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    This series contain 36 samples obtained from human lung tissue and includes the following: 7 Adenocarcinoma samples. 16 Squamous cell carcinoma samples. 1 AdenoSquamous sample. 2 Renal Metastasis. 1 Colon metastasis. 7 normal lung tissue adjacent to the tumors. 2 commercial normal lung RNA.

    Authors: Dehan E, Kaminski N

    Organization: Tel Aviv University Tel Aviv 69978 Count…

  • Cancer census - gene mutations in cancer and other diseases

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

    Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

    Organization: Cancer Genome Project, Human Genome Anal…
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Associated Researchers

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Thought leaders and organizations working on research involving MUC1.

View All Author iconAuthors
  • Donald Kufe
  • Surender Kharbanda
  • Deepak Raina
  • Sandra J Gendler
  • Takeshi Kawano
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of Pittsburgh
  • Dana-Farber Cancer Institute
  • Jonsson Comprehensive Cancer Center
  • Transgene
  • Mayo Clinic
View All Affiliations icon Organizations
  • Dana-Farber Cancer Institute
  • University of Pittsburgh School of Medicine
  • University of Chicago
  • Mayo Clinic College of Medicine
  • University of Cologne

Clinical Trials | 19 trials

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News | 1 story

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Community

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