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mitochondrial ribosomal protein L12

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene en...

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Data Correlations | 1,497 studies

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Tissues category icon Normal tissues
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Cecum 100 100
Epidermis 96 96
Skeletal muscle tiss… 93 93
Zygote 89 89
Vomeronasal organ 89 89
Tongue 87 87
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Compounds category icon Compounds
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Quinacrine 100 100
Topotecan Lactone 97 97
Methiazole 93 93
Ethoxyquin 91 91
Mephentermine 88 88
Racephenicol 86 86
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Diseases category icon Diseases
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Tenosynovial giant c… 100 100
Grade III acute reje… 99 99
Chronic hemorrhagic … 89 89
Anomaly of chromosom… 86 86
Grade I acute reject… 80 80
Benign neoplasm of f… 78 78
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Individual Studies

  • Heart, liver, muscle and adipose tissue from mice on standard, high calorie, or resveratrol diet

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Male C57BL/6NIA mice at one year of age, mice were fed a Standard Diet every day or Every other day (EOD) as well groups fed a standard diet plus 0.01% or 0.04% resveratrol for the duration of the study. Three separate groups were placed on an High Calorie diet (modified by the addition of hydrogena…

    Authors: Pearson J Kevin, Baur A Joseph, Lewis N Kaitlyn et al.

    Organization: National Institute on Aging, NIH Researc…
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Associated Researchers

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Thought leaders and organizations working on research involving MRPL12.

View All Author iconAuthors
  • Måns Ehrenberg
  • A I Mallick
  • Joachim Frank
  • Kevin S Wilson
  • W Wintermeyer
View All Affiliations icon Organizations
  • Aligarh Muslim University
  • University of Alberta
  • Ilam University of Medical Sciences
  • Institut National de la Recherche Agronomique
  • State University of New York at Albany

Community

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