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myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

The MLL gene encodes a DNA-binding protein that methylates histone H3 (see MIM 601128) lys4 (H3K4) and positively regulates expression of target genes, including multiple HOX genes (see MIM 142980). MLL is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia (AML; MIM 601626), acute lymphoblastic leukemia (ALL), or mixed lineage (biphenotypic) leukemia (MLL). Leukemias with translocations involving MLL possess unique clinical and biologic characteristics and are often associated with poor prognosis. MLL rearrangements are found in more than 70% of in...

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Data Correlations | 1,116 studies

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Tissues category icon Normal tissues
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Mesenteric lymph nod… 100 100
Preoptic area 91 91
Nipple 89 89
Segment of venous tr… 83 83
Ganglion of cranial … 82 82
Cecum 81 81
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Compounds category icon Compounds
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Tarenflurbil 100 100
Methoxsalen 88 88
Nsc102773 88 88
Denatonium Benzoate 82 82
Brinzolamide 78 78
Zinc00057500 76 76
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Diseases category icon Diseases
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Acute myelocytic leu… 100 100
Acute lymphocytic le… 100 100
Postpartum cardiomyo… 100 100
Endometrial carcinom… 95 95
Urinary tract infect… 94 94
Nephrotoxic acute re… 93 93
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Individual Studies

  • Mouse Phenotypes - Myeloid leukemia

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving MLL.

View All Author iconAuthors
  • Michael L Cleary
  • Jay L Hess
  • John H Kersey
  • Rob Pieters
  • Scott A Armstrong
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Children's Oncology Group
  • Masonic Cancer Center, University of Minnesota
  • Cancer and Leukemia Group B
  • Fred Hutchinson Cancer Research Center
  • Gruppo Italiano Malattie EMatologiche dell'Adulto
View All Affiliations icon Organizations
  • Stanford University School of Medicine
  • University of Pennsylvania School of Medicine
  • Institute of Cancer Research
  • Dana-Farber Cancer Institute
  • University of Minnesota Cancer Center

Clinical Trials | 69 trials

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News | 7 stories

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Community

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