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mediator of DNA-damage checkpoint 1
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq]
Normal tissues
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|---|---|---|---|
| Uterus |
100
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| Adrenal gland |
100
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| Salivary gland |
99
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| Femur |
98
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| Set of fingers |
97
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| Thyroid gland |
97
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Compounds
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|---|---|---|---|
| Zoxazolamine |
100
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| Orthanilamide |
93
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| Mexiletine |
92
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| Cyproterone Acetate |
91
|
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| Homosalate |
90
|
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| Ticlopidine |
88
|
 Individual Studies |
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Homo sapiens
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RNA Expression
Rattus norvegicus
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Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.
Authors: Velibor Savic, Bu Yin, Nancy L Maas, Andrea L Bredemeyer, Andrea C Carpenter, Beth A Helmink, Katherine S Yang-Iott, Barry P Sleckman, Craig H Bassing
Molecular cell 2009 May 15 -
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
Authors: Manuel Stucki, Julie A Clapperton, Duaa Mohammad, Michael B Yaffe, Stephen J Smerdon, Stephen P Jackson
Cell 2005 Dec 29
Thought leaders and organizations working on research involving MDC1.
- University of Cambridge
- Mayo Clinic
- Institute of Cancer Biology and Centre for Genotoxic Stress Research
- National Cancer Institute
- University of Sussex
