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Description: Synthetic 9 residue peptide analog of gonadotropin releasing hormone.
Drug Type: Biotech; Approved; Investigational
Pharmacology: Used in the palliative treatment of advanced prostate cancer. Leuprolide is a luteinizing hormone agonist that results in suppression of testicular or follicular steroidogenesis.
Mechanism of Action: Leuprolide binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion.
Indication: For treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty
Half Life: ~3 hours
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Data Correlations | 1 study

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Genes category icon Genes
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GNRHR 100 100
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Biogroups category icon Biogroups
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Peptide GPCRs 100 100
GnRH Signaling Pathway 98 98
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving Leuprolide.

View All Author iconAuthors
  • Andrew Zalewski
  • Stefano Palomba
  • Gen Sobue
  • Francesco Orio
  • Mark A Staples
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Abbott
  • National Center for Research Resources (NCRR)
  • M.D. Anderson Cancer Center
  • FDA Office of Orphan Products Development
  • National Institute of Mental Health (NIMH)
View All Affiliations icon Organizations
  • Nagoya University Graduate School of Medicine
  • MicroCHIPS Inc
  • Rashtrasant Tukadoji Maharaj Nagpur University
  • Hospital of the University of Pennsylvania
  • University of California

Clinical Trials | 273 trials

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