RESEARCH
PUBLICATIONS
NEXTBIO COMMUNITY
low density lipoprotein-related protein 2
Lipoprotein receptor-related protein-2 (LRP2), also called glycoprotein-330 or megalin (Farquhar, 1995 [PubMed 7657789]), is part of the Heymann nephritis antigenic complex with RAP (LRPAP1; MIM 104225) (Farquhar et al., 1995 [PubMed 7579068]) and is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (LDLR; MIM 606945).[supplied by OMIM]
Normal tissues
|
|
||
|---|---|---|---|
| Thyroid gland |
100
|
||
| Cortex of kidney |
98
|
||
| Globus pallidus |
97
|
||
| Inferior ganglion of… |
94
|
||
| Subthalamic nucleus |
90
|
||
| Substantia nigra |
87
|
Compounds
|
|
||
|---|---|---|---|
| Butyric Acid, Sodium… |
100
|
||
| Retinoic Acid |
97
|
||
| Atrazine |
95
|
||
| Deamino Arginine Vas… |
91
|
||
| Carbon-14c Dioxide |
90
|
||
| Clco |
89
|
Diseases
|
|
||
|---|---|---|---|
| Fanconi syndrome |
100
|
||
| Breast cancer |
75
|
||
| N2 |
75
|
||
| Lymph node metastase… |
68
|
||
| Basal cell carcinoma |
64
|
||
| Oncocytoma of kidney |
63
|
 Individual Studies |
|
|---|---|
|
|
Mus musculus
|
Mutations/Phenotypic
Homo sapiens
|
RNA Expression
-
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes.
Authors: Sibel Kantarci, Lihadh Al-Gazali, R Sean Hill, Dian Donnai, Graeme C M Black, Eric Bieth, Nicolas Chassaing, Didier Lacombe, Koen Devriendt, Ahmad Teebi,…
Nature genetics 2007 Aug -
Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros.
Authors: Uwe Anzenberger, Nana Bit-Avragim, Stefan Rohr, Franziska Rudolph, Bastian Dehmel, Thomas E Willnow, Salim Abdelilah-Seyfried
Journal of cell science 2006 May 15
Thought leaders and organizations working on research involving LRP2.
- Vanderbilt University
- National Institute of Allergy and Infectious Diseases (NIAID)
- University of California
- Niigata University Graduate School of Medical and Dental Sciences
- Max Delbrueck Center for Molecular Medicine
- Universidad de Salamanca
- Uppsala University
-
Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation
conditions: Parkinson's Disease ; Essential Tremor ; Dystonia
interventions: Dexmedetomidine Hydrochloride Infusion ; Normal Saline
-
Safety and Effectiveness of Lopinavir/Ritonavir in Individuals Who Have Failed Prior HIV Therapy
conditions: HIV Infections
interventions: Emtricitabine/Tenofovir disoproxil fumarate ; Lopinavir/Ritonavir
