KRAS - NextBio

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Search Term: KRAS (gene)

Overview

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq]

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Data Correlations | 1,388 studies

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Normal tissues

Score

Cecum

100

Caudate nucleus

Intestine

Preoptic area

Substantia nigra

Vomeronasal organ

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Compounds

Score

Lampit

100

Methyl Paraben

Zomepirac

Pyrazinamide

Ribosomal Rna

Glycol, Polyethylene

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Diseases

Score

Costello syndrome

100

Noonan syndrome

Neoplasm of lower re…

cancer of endocrine …

Neoplasm of pancreas

Bladder cancer

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Individual Studies
Mouse Phenotypes - Neoplasms score: 100 \| Mus musculus \| Mutations/Phenotypic This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni… Source: NextBio Library/Mutation and Phenotypic data	Cancer census - gene mutations in cancer and other diseases score: 100 \| Homo sapiens \| Mutations/Phenotypic The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al. Organization: Cancer Genome Project, Human Genome Anal…

Individual Studies

Mouse Phenotypes - Neoplasms

score: 100 | Mus musculus | Mutations/Phenotypic

This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

Source: NextBio Library/Mutation and Phenotypic data

Cancer census - gene mutations in cancer and other diseases

score: 100 | Homo sapiens | Mutations/Phenotypic

The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

Organization: Cancer Genome Project, Human Genome Anal…