KDR - NextBio

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Search Term: KDR (gene)

Overview

kinase insert domain receptor (a type III receptor tyrosine kinase)

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile...

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Data Correlations | 1,024 studies

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Normal tissues

Score

Pericardium

100

Thyroid gland

Mesenteric lymph nod…

Adrenal cortex

Myometrium

Cardia of stomach

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Compounds

Score

Sorafenib

100

100

Paeonol

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Diseases

Score

Hemangioma

100

Metastasis from mali…

100

Clear cell carcinoma…

Renal cell carcinoma

Injury of artery

Knee osteoarthritis

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Individual Studies
Normal and carcinoma associated prostate fibroblasts overexpressing Cyclin D1 score: 100 \| Homo sapiens \| RNA Expression The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote… Authors: He Y, Franco OE, Williams K et al. Organization: Fred Hutchinson Cancer Research Center H…	OMIM - Hemangioma score: 100 \| Homo sapiens \| Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data

Individual Studies

Normal and carcinoma associated prostate fibroblasts overexpressing Cyclin D1

score: 100 | Homo sapiens | RNA Expression

The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote…

Authors: He Y, Franco OE, Williams K et al.

Organization: Fred Hutchinson Cancer Research Center H…

OMIM - Hemangioma

score: 100 | Homo sapiens | Mutations/Phenotypic

This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

Source: NextBio Library/Mutation and Phenotypic data