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Janus kinase 2

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq]

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Data Correlations | 1,615 studies

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Tissues category icon Normal tissues
Score Help
Mesenteric lymph nod… 100 100
Great saphenous vein 98 98
Aorta 95 95
Vagina 93 93
Zygote 93 93
Superior surface of … 91 91
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Compounds category icon Compounds
Score Help
Dimethadione 100 100
Scopoletin 100 100
Chel 330 Acid 86 86
Articaine 86 86
C14209 83 83
Zinc08406352 83 83
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Diseases category icon Diseases
Score Help
Budd-Chiari syndrome 100 100
Myelofibrosis 100 100
Polycythemia vera 100 100
Myeloproliferative d… 100 100
Thrombocytosis 99 99
Acute lymphocytic le… 98 98
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Individual Studies

  • OMIM - Bone marrow disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • OMIM - Malignant neoplasms

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving JAK2.

View All Author iconAuthors
  • William Vainchenker
  • Radek C Skoda
  • D Gary Gilliland
  • Anthony R Green
  • Ross L Levine
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Exelixis
  • TargeGen
  • Myeloproliferative Disorders-Research Consortium
  • Weill Medical College of Cornell University
  • M.D. Anderson Cancer Center
View All Affiliations icon Organizations
  • University Hospital Basel
  • Brigham and Women's Hospital
  • University of Cambridge
  • St Jude Children's Research Hospital
  • Center for Molecular Medicine of the Austrian Academy of Sciences

Clinical Trials | 26 trials

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Community

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View All NextBio Users | 3 people
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