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immunity-related GTPase family, M

Members of the p47 immunity-related GTPase (IRG) family, including IRGM, play an important role in the murine immune system; however, in humans this resistance system is greatly reduced. There is evidence that human IRGM plays a role in autophagy and control of intracellular mycobacteria (Bekpen et al., 2005; Singh et al., 2006 [PubMed 16888103]).[supplied by OMIM]

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Data Correlations | 678 studies

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Tissues category icon Normal tissues
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Mesenteric lym… 100 100
Epidermis 95 95
Preoptic area 91 91
Dorsal striatu… 91 91
Cecum 91 91
Set of fingers 91 91
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Compounds category icon Compounds
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Dinitrophenyle… 100 100
Interferon Gam… 99 99
C00929 97 97
Paeonol 94 94
Peoniflorin 93 93
Oxypaeoniflora 91 91
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Diseases category icon Diseases
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Streptococcus … 100 100
Trypanosomiasi… 94 94
Gastroenteriti… 92 92
Anthrax 84 84
Scrapie 83 83
Infectious col… 81 81
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Individual Studies

  • HDACI treatment of hepG2 cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    This study compares HEPG2 cells treated with either ethanol(control) or TSA (0.5uM) for 24 hrs. Gene Expression was profiled on HU-133 plus 2.0 arrays

    Authors: Chittur SV, Marcy KL, Paulette MJ

    Organization: SUNY-University at Albany Center for Fun…

  • Diverse liver drug signatures

    score: 9999 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "Classification of a large micro-array dataset. Algorithm comparison and analysis of drug signatures".

    Authors: Natsoulis Georges, El Ghaoui Laurent, Lanckriet R Gert et al.

    Organization: Iconix Biosciences 325 East Middlefield …
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Associated Researchers

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Thought leaders and organizations working on research involving IRGM.

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  • Gregory A Taylor
  • Alan Sher
  • Vojo Deretic
  • Ramnik J Xavier
  • Alan Huett
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Hadassah Medical Organization
View All Affiliations icon Organizations
  • National Institute of Allergy and Infectious Diseases
  • Massachusetts General Hospital
  • University of Montreal
  • University of New Mexico Health Sciences Center
  • Bernhard Nocht Institute for Tropical Medicine

Clinical Trials | 1 trial

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News | 2 stories

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Community

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