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interferon regulatory factor 1

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq]

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Data Correlations | 1,647 studies

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Tissues category icon Normal tissues
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Mesenteric lym… 100 100
Superior vena … 95 95
Cecum 85 85
Large intestin… 85 85
T lymphocyte 84 84
Duodenum 82 82
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Compounds category icon Compounds
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Interferon Gam… 100 100
Cephaelin 72 72
Aids070130 72 72
Infergen 72 72
C00929 71 71
Midkine 69 69
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Diseases category icon Diseases
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Macrocytic ane… 100 100
Dysmyelopoieti… 100 100
Myeloid leukem… 99 99
Non-small cell… 98 98
Stomach diseas… 98 98
Haemophilus in… 85 85
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Individual Studies

  • OMIM - Anemia

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • OMIM - Malignant neoplasms

    score: 9999 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving IRF1.

View All Author iconAuthors
  • Antai Wang
  • Kyung-Hyun Park-Min
  • Bo Jiang
  • Jide Wang
  • Bing Zou
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
  • AstraZeneca
View All Affiliations icon Organizations
  • Hospital for Special Surgery
  • Southern Medical University
  • University of Tokyo
  • University Health Network
  • Georgetown University School of Medicine

Clinical Trials | 2 trials

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