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interleukin 8 receptor, beta

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. ...

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Data Correlations | 672 studies

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Tissues category icon Normal tissues
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Femur 100 100
Vomeronasal organ 87 87
Viscerocranial mucos… 86 86
Vulva 83 83
Mesenteric lymph nod… 82 82
Esophagus 81 81
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Compounds category icon Compounds
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Crystal Violet 100 100
Infliximab 77 77
Benzethonium 76 76
Metolazone 73 73
Prestwick_154 70 70
4-methyl-N-[[2-(4-me… 66 66
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Diseases category icon Diseases
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Accelerated phase ch… 100 100
Ventilator-associate… 80 80
Acute promyelocytic … 77 77
Chronic myeloid leuk… 74 74
Aseptic necrosis of … 74 74
Dehydration 72 72
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Individual Studies

  • RNAi analysis of the FBP transactivator family

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The three far-upstream element (FUSE) binding protein (FBP) family members have been ascribed different functions in gene regulation. Their function were studied using RiRNA.

    Authors: 16914741

    Organization: NIH NCI/CCR LP 10 Center Drive Bethesda …
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Associated Researchers

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Thought leaders and organizations working on research involving IL8RB.

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  • Søren G F Rasmussen
  • Krzysztof Palczewski
  • Brian K Kobilka
  • Daniel M Rosenbaum
  • Gebhard F X Schertler
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Sha’ar Menashe Mental Health Center
  • Eastern Cooperative Oncology Group
  • National Taiwan University Hospital
View All Affiliations icon Organizations
  • Stanford University School of Medicine
  • Lerner Research Institute
  • University of Nebraska Medical Center
  • Schering-Plough Research Institute
  • University of California

Clinical Trials | 3 trials

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Community

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NextBio Groups

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