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interleukin 6 signal transducer (gp130, oncostatin M receptor)
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulat...
Normal tissues
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|---|---|---|---|
| Pericardium |
100
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| Great saphenous vein |
97
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| Vagina |
96
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| Synovial membrane |
94
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| Fetal organ |
92
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| Subcutaneous adipose… |
91
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Compounds
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|---|---|---|---|
| Paroxetine Maleate |
100
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| Clindamycin |
89
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| Levoleucovorin Calci… |
80
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| Ursolic Acid |
76
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| Clenbuterol |
76
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| Nicardipine |
76
|
 Individual Studies |
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Homo sapiens
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RNA Expression
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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours.
Authors: Sandra Rebouissou, Mohamed Amessou, Gabrielle Couchy, Karine Poussin, Sandrine Imbeaud, Camilla Pilati, Tina Izard, Charles Balabaud, Paulette Bioulac-Sage, Jessica Zucman-Rossi
Nature 2009 Jan 8 -
Structural biology of shared cytokine receptors.
Authors: Xinquan Wang, Patrick Lupardus, Sherry L Laporte, K Christopher Garcia
Annual review of immunology 2009
Thought leaders and organizations working on research involving IL6ST.
- Ludwig Institute for Cancer Research
- Stanford University School of Medicine
- Technical University Munich
- University of Heidelberg
- University of California, San Diego
