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interleukin 5 (colony-stimulating factor, eosinophil)

The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytok...

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Data Correlations | 341 studies

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Tissues category icon Normal tissues
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Epidermis 100 100
Stomach 93 93
Ganglion of cranial … 91 91
Caudate nucleus 90 90
Zygote 89 89
Thyroid gland 89 89
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Compounds category icon Compounds
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Csc Cpd 100 100
Neuromedin U 77 77
CID 5140203 72 72
Sulfaphenazole 63 63
2-(3-fluorophenyl)et… 57 57
Megestrol Acetate 52 52
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Diseases category icon Diseases
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Squamous cell carcin… 100 100
General adaptation s… 93 93
Congenital absence o… 92 92
House dust mite alle… 91 91
Asthma 88 88
Cytomegalovirus infe… 86 86
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Individual Studies

  • Gene Expression-Based High Throughput Screening in HL-60

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    We developed a general approach to small molecule library screening called GE-HTS (Gene Expression-Based High Throughput Screening) in which a gene expression signature is used as a surrogate for cellular states and applied it to the identification of compounds inducing the differentiation of acute …

    Authors: Stegmaier K, Ross KN, Colavito SA et al.

    Organization: Broad Institute Cancer Genomics Golub La…
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Associated Researchers

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Thought leaders and organizations working on research involving IL5.

View All Author iconAuthors
  • Marc E Rothenberg
  • Angel F Lopez
  • Tetsuya Ishino
  • Irwin Chaiken
  • Michael W Parker
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • GlaxoSmithKline
  • National Taiwan University Hospital
  • Novartis
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • The University of Texas Health Science Center, Houston
View All Affiliations icon Organizations
  • University of Cincinnati College of Medicine
  • Drexel University College of Medicine
  • University of Toyama
  • University of California
  • National Heart and Lung Institute

Clinical Trials | 48 trials

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Community

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NextBio Groups

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