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interleukin 4

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase r...

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Data Correlations | 488 studies

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Tissues category icon Normal tissues
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Vomeronasal organ 100 100
Adrenal gland 100 100
Oocyte 100 100
Caudate nucleus 100 100
Cecum 99 99
Ganglion of cranial … 99 99
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Compounds category icon Compounds
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Mrk 100 100
Neuromedin U 82 82
Pyromellitic Acid 75 75
Staphylococcal Enter… 64 64
Ionomycin 63 63
Immunoglobulins, E 57 57
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Diseases category icon Diseases
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Sjogren's syndrome 100 100
Insulin dependent di… 99 99
Helicobacter-associa… 99 99
Chronic lymphocytic … 93 93
Colon Cancer 90 90
Adenocarcinoma of pr… 89 89
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Individual Studies

  • Mouse Phenotypes - Collagen diseases

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data

  • FBW7 mutation in human T cell leukemia cell lines

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The NOTCH signaling cascade, which is deregulated in T-cell acute lymphoblastic leukemia (T-ALL) and many other human cancers, offers an attractive target for molecular therapy. One approach employs gamma-secretase inhibitors (GSIs) to suppress production of the intracellular form of NOTCH (NICD), …

    Authors: O'Neil Jennifer, Grim Jonathan, Strack Peter et al.

    Organization: Rosetta Inpharmatics Informatics 401 Ter…
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Associated Researchers

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Thought leaders and organizations working on research involving IL4.

View All Author iconAuthors
  • K Mark Ansel
  • Anjana Rao
  • Liying Guo
  • William E Paul
  • Masato Kubo
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Creighton University
  • National Taiwan University Hospital
  • UPECLIN HC FM Botucatu Unesp
View All Affiliations icon Organizations
  • University of Oxford
  • RIKEN Yokohama Institute
  • Stanford University School of Medicine
  • University of Washington
  • National institute of Allergy and Infectious Diseases

Clinical Trials | 100 trials

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Community

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