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interleukin 2 receptor, alpha

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. [provided by RefSeq]

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Data Correlations | 762 studies

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Tissues category icon Normal tissues
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Superior cervical ga… 100 100
Parietal lobe 94 94
T lymphocyte 94 94
Trigeminal ganglion 93 93
Salivary gland 90 90
Substantia nigra 87 87
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Compounds category icon Compounds
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Ontak 100 100
Simulect 100 100
Dacliximab 100 100
Proleukin (tn) 99 99
Staph Enterotoxin B 71 71
Baker's Yeast (sacch… 59 59
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Diseases category icon Diseases
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Ulcerative colitis 100 100
Diabetes mellitus ty… 100 100
Infection by Aspergi… 74 74
House dust mite alle… 69 69
Staphylococcus aureu… 68 68
Cytomegalovirus infe… 62 62
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • CD4+ memory T cells are preferential targets for bystander activation and apoptosis

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Three types of T cells were compared: Resting cells - cells expressing a TCR which does not specifically recognize SEB (Vβ13.1 T cells) and did not upregulate the activation marker CD25 in response to transwell SEB-stimulated co-culture over a 5 day period. Bystander activated cells - cells expres…

    Authors: Bangs C Sarah, Baban Dilair, Cattan J Helen et al.

    Organization: University of Oxford Wellcome Trust Cent…
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Associated Researchers

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Thought leaders and organizations working on research involving IL2RA.

View All Author iconAuthors
  • John A Todd
  • Linda S Wicker
  • Jason D Cooper
  • Sarah Nutland
  • Thomas R Malek
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Cancer Institute (NCI)
  • Eisai Inc.
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • Ohio State University Comprehensive Cancer Center
  • Masonic Cancer Center, University of Minnesota
View All Affiliations icon Organizations
  • University of Cambridge
  • McGill University Health Center
  • Stanford University School of Medicine
  • University of Miami
  • University of Manchester

Clinical Trials | 70 trials

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Community

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