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interleukin 23, alpha subunit p19

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq]

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Data Correlations | 858 studies

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Tissues category icon Normal tissues
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Salivary gland 100 100
Caudate nucleus 99 99
Appendix 99 99
Cecum 98 98
Adrenal gland 98 98
Substantia nigra 98 98
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Compounds category icon Compounds
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Sulfasalazine 100 100
Vinyl Acetate, Dibut… 99 99
Pentam 300 (as Iseth… 98 98
Phma 97 97
Antigens 94 94
Imipramine 93 93
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Diseases category icon Diseases
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Mycosis fungoides 100 100
Tularemia 86 86
Staphylococcus aureu… 78 78
Chlamydial infection 77 77
Multiple benign mela… 70 70
Primary cutaneous B-… 68 68
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Individual Studies

  • Murine T cell response to IL-2 treatment

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    The cytokine IL-2 determines T cell fate by controlling T cell proliferation and differentiation, but the expression files of IL-2 regulated genes are not defined

    Authors: Zhang Zhaoduo, Martino Anthony, Faulon Jean-Loup

    Organization: Sandia National Labs Biosystems 7011 Eas…

  • Cartilage Destruction in Rheumatoid Arthritis

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    We have studied the expression profile of 3D cultured human chondrocytes that were stimulated with supernatant of synovial fibroblasts derived from a RA patient (RASF=HSE cell line) and from a normal donor (NDSF=K4IM cell line), respectively. For this purpose, passage 2 human chondrocytes were cultu…

    Authors: Andreas K, Lübke Cbke C, HAupl T et al.

    Organization: Charit? Rheumatology Tucholskystr. 2 Ber…
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Associated Researchers

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Thought leaders and organizations working on research involving IL23A.

View All Author iconAuthors
  • Daniel J Cua
  • Robert A Kastelein
  • Estelle Bettelli
  • Dan R Littman
  • Yi Chen
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Centocor, Inc.
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Synta Pharmaceuticals, Corp.
  • Vanderbilt-Ingram Cancer Center
  • Indiana University
View All Affiliations icon Organizations
  • New York University School of Medicine
  • Yale University School of Medicine
  • Trudeau Institute
  • DNAX Research Inc
  • Brigham and Women's Hospital

Clinical Trials | 12 trials

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Community

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