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interleukin 2

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq]

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Data Correlations | 389 studies

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Tissues category icon Normal tissues
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Peripheral blood mon… 100 100
Caudate nucleus 94 94
Salivary gland 92 92
T lymphocyte 90 90
Set of fingers 89 89
Spinal cord 89 89
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Compounds category icon Compounds
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Staphylococcal Enter… 100 100
Noc 18 78 78
4-methyl-N-[[2-(4-me… 61 61
Phytohemagglutinin 60 60
Phma 57 57
Staph Enterotoxin B 55 55
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Diseases category icon Diseases
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Enteropathy-associat… 100 100
Regional enteritis 99 99
Colitis 92 92
Chronic digestive sy… 92 92
Gastrointestinal ulc… 91 91
Hereditary disorder … 91 91
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Individual Studies

  • Nucleosome positioning in human CD4+ activated T cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The positioning of nucleosomes with respect to DNA plays an important role in regulating transcription. However, nucleosome mapping has been performed for only limited genomic regions in humans. We have generated genome-wide maps of nucleosome positions in both resting and activated human CD4+ T c…

    Authors: Schones E Dustin, Cui Kairong, Cuddapah Suresh et al.

    Organization: NHLBI/NIH Zhao Lab Building 10, Room 7B2…

  • Human PBMC treated with S. aureus superantigen

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    PBMCs from 3 healthy blood donors were purified and treated with Medium (control) and recombinant staphylococcal superantigens SEB and SEI.

    Authors: Grumann Dorothee, Scharf S Sandra, Holtfreter Silva et al.

    Organization: Ernst Moritz Arndt University Greifswald…
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Associated Researchers

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Thought leaders and organizations working on research involving IL2.

View All Author iconAuthors
  • John A Todd
  • Linda S Wicker
  • Kendall A Smith
  • Lude Franke
  • Thomas A Waldmann
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • Baylor College of Medicine
  • Fred Hutchinson Cancer Research Center
  • National Cancer Institute (NCI)
  • UPECLIN HC FM Botucatu Unesp
View All Affiliations icon Organizations
  • University of California
  • National Cancer Institute
  • University of Washington
  • Emory University School of Medicine
  • University of Calgary

Clinical Trials | 463 trials

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Community

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