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interleukin 18 (interferon-gamma-inducing factor)

The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq]

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Data Correlations | 1,137 studies

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Tissues category icon Normal tissues
Score Help
Epidermis 100 100
Set of fingers 94 94
Cecum 91 91
Esophagus 91 91
Tongue 91 91
Viscerocranial mucos… 89 89
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Compounds category icon Compounds
Score Help
Oils, Blackberry 100 100
Deferasirox 96 96
Zirconium Chloride (… 85 85
Bretylium Tosylate (… 81 81
Rifampicin 79 79
Lactic Acid 78 78
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Diseases category icon Diseases
Score Help
Very mild acute reje… 100 100
Primary cutaneous di… 91 91
Haemophilus infectio… 83 83
cancer of hypopharyn… 79 79
Human anaplasmosis 76 76
Metastasis to brain 71 71
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Individual Studies

  • Progerin-induced changes in hTERT cell line gene expression

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by constitutive production of progerin, a mutant form of the nuclear architectural protein lamin A1. Progerin is also sporadically expressed in wild type cells and has been linked to physiological aging. HGPS cells e…

    Authors: Scaffid Paola, Misteli Tom

    Organization: NCI, NIH 41 Library Drive, B508 Bethesda…
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Associated Researchers

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Thought leaders and organizations working on research involving IL18.

View All Author iconAuthors
  • Kenji Nakanishi
  • Shizuo Akira
  • Charles A Dinarello
  • Tomohiro Yoshimoto
  • Howard A Young
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
  • University of Alabama at Birmingham
  • University of Alberta
  • Austin Health
  • IKFE Institute for Clinical Research and Development
View All Affiliations icon Organizations
  • Institute for Advanced Medical Sciences
  • University of Michigan Medical School
  • Hyogo College of Medicine
  • University of Zurich
  • Harvard School of Public Health

Clinical Trials | 28 trials

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News | 1 story

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Community

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View All NextBio Users | 1 person
NextBio Groups

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