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interleukin 13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [pr...

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Data Correlations | 540 studies

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Tissues category icon Normal tissues
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Core region of nucle… 100 100
Nucleus accumbens 89 89
Shell region of nucl… 81 81
Ventral tegmental ar… 80 80
Caudate nucleus 80 80
Salivary gland 79 79
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Compounds category icon Compounds
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Pyromellitic Acid 100 100
Ionomycin 90 90
Staphylococcal Enter… 84 84
C14209 76 76
Cefotaxime 71 71
Olive Oil (tn) 69 69
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Diseases category icon Diseases
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Allergic rhinitis 100 100
Asthma 99 99
Smallpox 86 86
Mucocutaneous lymph … 80 80
Ebola hemorrhagic fe… 76 76
Azoospermia 62 62
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Individual Studies

  • OMIM - Hypersensitivity

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Comparison of CD4+ T lymphocytes transferred between mouse knockouts

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Th17 cells are enriched by sorting FR4-CD4+ T cells from SKG mice. A large number of Th17 cells also develop spontaneously when CD4+ T cells from IFN-g-deficient (IFN-g-/-) BALB/c mice are transferred to T cell-deficient RAG2-deficient (RAG2-/-) mice and subjected to homeostatic proliferation, where…

    Authors: Hirota K, Yoshitomi H, Hashimoto M et al.

    Organization: Institute for Frontier Medical Sciences …
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Associated Researchers

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Thought leaders and organizations working on research involving IL13.

View All Author iconAuthors
  • Warren Strober
  • Atsushi Kitani
  • Raj K Puri
  • Stefan Fichtner-Feigl
  • Hisamichi Aizawa
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Neopharm
  • Creighton University
  • National Taiwan University Hospital
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • University of Pittsburgh
View All Affiliations icon Organizations
  • National Institute of Allergy and Infectious Diseases
  • University of Regensburg
  • Wake Forest University School of Medicine
  • Kyushu University
  • National institutes of Allergy and Infectious Diseases

Clinical Trials | 54 trials

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Community

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