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interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathoge...
Normal tissues
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|---|---|---|---|
| Adrenal gland |
100
|
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| Mesenteric lymph nod… |
96
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| Superior cervical ga… |
94
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| Zygote |
94
|
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| Core region of nucle… |
93
|
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| Caudate nucleus |
93
|
Compounds
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|
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|---|---|---|---|
| Lactobacillus Acidop… |
100
|
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| Baker's Yeast (sacch… |
98
|
||
| Guanylic Acid |
95
|
||
| Oligodeoxyribonucleo… |
92
|
||
| Aids070130 |
88
|
||
| Lysophosphotidylseri… |
86
|
Diseases
|
|
||
|---|---|---|---|
| Disseminated atypica… |
100
|
||
| Psoriasis |
98
|
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| Asthma |
97
|
||
| Tularemia |
97
|
||
| Infection by Aspergi… |
86
|
||
| Staphylococcus aureu… |
72
|
 Individual Studies |
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|---|---|
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Mus musculus
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RNA Expression
Homo sapiens
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A functional promoter variant in IL12B predisposes to cerebral malaria.
Authors: Sandrine Marquet, Ogobara Doumbo, Sandrine Cabantous, Belco Poudiougou, Laurent Argiro, Innocent Safeukui, Salimata Konate, Sibiri Sissoko, Estelle Chevereau, Abdoulaye Traore,…
Human molecular genetics 2008 Jul 15 -
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
Authors: Michele Cargill, Steven J Schrodi, Monica Chang, Veronica E Garcia, Rhonda Brandon, Kristina P Callis, Nori Matsunami, Kristin G Ardlie, Daniel Civello, Joseph J Catanese,…
American journal of human genetics 2007 Feb
Thought leaders and organizations working on research involving IL12B.
- Walter and Eliza Hall Institute of Medical Research
- Osaka University
- University of Michigan
- University of Western Australia
- Indiana University School of Medicine
