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interleukin 11 receptor, alpha

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. [provided by RefSeq]

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Data Correlations | 1,304 studies

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Tissues category icon Normal tissues
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Vomeronasal organ 100 100
Epidermis 92 92
Set of fingers 86 86
Thyroid gland 84 84
Uterus 78 78
Zygote 77 77
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Compounds category icon Compounds
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Oprelvekin 100 100
Gibberellic Acid 68 68
Piperacillin 63 63
Betonicine 61 61
Zinc08406352 61 61
Novocainamide 57 57
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Diseases category icon Diseases
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Helicobacter-associa… 100 100
Septic enteritis 91 91
Smallpox 86 86
Contusions 85 85
Liposarcoma 83 83
Invasive ductal carc… 81 81
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    score: 9999 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving IL11RA.

View All Author iconAuthors
  • Evdokia Dimitriadis
  • Premila Paiva
  • Lois Salamonsen
  • Ellen Menkhorst
  • C G Begley
View All Affiliations icon Organizations
  • Prince Henry's Institute of Medical Research
  • Weill Cornell Medical College
  • Walter and Eliza Hall Institute of Medical Research
  • University of Florida College of Medicine
  • University of Texas Medical Branch

Community

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