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immunoglobulin lambda variable group

Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains (see MIM 147100) and 2 identical light chains, either kappa (see MIM 147200) or lambda, joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. The kappa and lambda light chains have no apparent functional differences. Each Ig lambda light chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (IGLC1; MIM 147220), that provides signaling functions. The lambda light chain V re...

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Data Correlations | 3 studies

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Geneticperturbations category icon Gene perturbations
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Dmel_CG10388 gene 100 100
H2-Eb1 gene 99 99
Dmel_CG3830 gene 97 97
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Individual Studies

  • Generation and purification of Th1 and Th2 effector and memory CD4+ T cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Naïve CD4+ T cells were isolated from spleen of AND TcR transgenic/green fluorescence protein (GFP) transgenic mice (Kaye et al., Nature 1989;341:746, Wright et al, Blood 2001;97:2278) that recognize a peptide of pigeon cytochrome C in the context of I-Ek and express CD44lo, CD62Lhi, CD45RBhi, and C…

    Authors: McKinstry KK, Golech Susanne, Lee H W et al.

    Organization: National Institute on Aging, NIH Researc…

  • The UBX-regulated network in the haltere imaginal disc of D. melanogaster

    score: 6767 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Hox proteins have been proposed to act at multiple levels within regulatory hierarchies and to directly control the expression of a plethora of target genes. However, for any specific Hox protein or tissue, very few direct in vivo-regulated target genes have been identified.

    Authors: Hersh BM, Nelson CE, Stoll SJ et al.

    Organization: Clemson University Biological Sciences 1…
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Associated Researchers

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Thought leaders and organizations working on research involving IGLV@.

View All Author iconAuthors
  • Achilles Anagnostopoulos
  • Nikolaos Laoutaris
  • Marie-Paule Lefranc
  • Chrysoula Belessi
  • Kostas Stamatopoulos
View All Affiliations icon Organizations
  • G. Papanicolaou Hospital
  • Université Montpellier II
  • Institute of Agrobiotechnology
  • Universidade de São Paulo
  • Guy's King's and St Thomas' Medical School

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