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insulin-like growth factor binding protein 1

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq]

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Data Correlations | 616 studies

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Tissues category icon Normal tissues
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Myometrium 100 100
Placenta 99 99
Fetal structure 98 98
Pericardium 96 96
Liver 88 88
Caudate nucleus 86 86
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Compounds category icon Compounds
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Medroxyprogesterone … 100 100
Arsenic(iii) Oxide 95 95
Tibolone 89 89
Paracetamol Pyroglut… 89 89
Zinc00163599 83 83
Phenobarbital 75 75
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Diseases category icon Diseases
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Coccidiosis 100 100
Social environment r… 92 92
Neoplasm of kidney 87 87
Endometriosis of pel… 85 85
Food deprivation 83 83
Benign neoplasm of f… 78 78
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Individual Studies

  • Five tissues from HSL knock-out versus wild type mice

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Gene expression profiling in 5 tissues (WAT, BAT, CM, LIV, SM) from HSL-/- mice versus wildtype (HSL+/+) mice.

    Source: NextBio Library/Metabolic disorders and Obesity

  • Placental malaria genome-wide analysis

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Chronic inflammation during placental malaria (PM) caused by Plasmodium falciparum is most frequent in first-time mothers and is associated with poor maternal and fetal outcomes. In the first genome wide analysis of the local human response to sequestered malaria parasites, we identified genes assoc…

    Authors: Muehlenbachs A, Duffy PE, Fried M et al.

    Organization: Seattle Biomedical Research Institute 30…
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Associated Researchers

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Thought leaders and organizations working on research involving IGFBP1.

View All Author iconAuthors
  • Fuller W Bazer
  • Barbara J Boucher
  • Michael N Pollak
  • Victor K M Han
  • Susan E Hankinson
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of California, San Francisco
  • FDA Office of Orphan Products Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human De…
  • Medical University of Vienna
  • Eli Lilly and Company
View All Affiliations icon Organizations
  • Dana-Farber Cancer Institute
  • Karolinska Institutet
  • Harvard Medical School
  • Buck Institute for Age Research
  • University of Pennsylvania School of Medicine

Clinical Trials | 5 trials

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Community

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