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insulin-like growth factor 1 receptor

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq]

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Data Correlations | 1,959 studies

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Tissues category icon Normal tissues
Score Help
Vomeronasal organ 100 100
Uterine tube 98 98
Medulla of kidney 96 96
Segment of venous tr… 91 91
Cortex of kidney 89 89
Breast 84 84
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Compounds category icon Compounds
Score Help
Mecasermin 100 100
Tamoxifen Citrate 89 89
8-aminohexylamino-ad… 67 67
Staurosporine 60 60
Bicalutamide 55 55
Androstanolone 55 55
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Diseases category icon Diseases
Score Help
Cryptorchidism, unil… 100 100
Adenocarcinoma of pr… 97 97
Breast cancer 82 82
Hodgkin's disease 81 81
Hemorrhage 77 77
Cryptorchidism, bila… 77 77
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Individual Studies

  • Molecular Correlate to Gleason Grade in Prostate Adenocarcinoma

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    12 Gleason pattern 3, 12 Gleason pattern 4, and 8 Gleason pattern 5 laser capture microdissected prostate cancers hybridized against patient-matched normal-adjacent controls.

    Source: NextBio Library/Oncology

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving IGF1R.

View All Author iconAuthors
  • V M Macaulay
  • Joan M Carboni
  • Neil M McKern
  • Arthur Weiss
  • Lee Helman
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Pfizer
  • North Central Cancer Treatment Group
  • Sanofi-Aventis
  • National Cancer Institute (NCI)
  • M.D. Anderson Cancer Center
View All Affiliations icon Organizations
  • University of Oxford
  • Rockefeller University
  • Yale University School of Medicine
  • Max Planck Institute for Biochemistry
  • Weatherall Institute of Molecular Medicine

Community

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