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insulin-like growth factor 1 (somatomedin C)

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

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Data Correlations | 1,656 studies

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Tissues category icon Normal tissues
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Pericardium 100 100
Myometrium 80 80
Peritoneum 76 76
Vagina 71 71
Cervix of uterus 70 70
Synovial membrane 64 64
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Compounds category icon Compounds
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Colony Stimulating F… 100 100
Chloranol 66 66
Conjugated Linoleic … 64 64
C12063 57 57
Tibolone 51 51
Deferasirox 51 51
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Diseases category icon Diseases
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Hypertrophic cardiom… 100 100
Gastric cancer 98 98
Lobular carcinoma 94 94
Metastasis from mali… 92 92
Invasive ductal carc… 91 91
Benign neoplasm of p… 90 90
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Individual Studies

  • Expression Profiles in Macrophages During Maturation and Polarization

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Monocytes were cultured in the presence of M-CSF for 7 days, and then polarized to M1 or M2 cells. The study includes Monocytes at day 0, macrophages at day 3 and 7, M1 and m2 polarized macrophages.

    Authors: Martinez Fernando

    Organization: University of Milan Via Magiagalli 31 Mi…
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Associated Researchers

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Thought leaders and organizations working on research involving IGF1.

View All Author iconAuthors
  • Herbert Yu
  • Shoshana Yakar
  • Thomas E Rohan
  • Peter J Houghton
  • Gloria Y F Ho
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Pfizer
  • FDA Office of Orphan Products Development
  • National Center for Research Resources (NCRR)
  • Assistance Publique - Hôpitaux de Paris
  • National Heart, Lung, and Blood Institute (NHLBI)
View All Affiliations icon Organizations
  • Albert Einstein College of Medicine
  • University of Texas M.D. Anderson Cancer Center
  • St. Jude Children's Research Hospital
  • University of Washington
  • Mayo Clinic College of Medicine

Clinical Trials | 87 trials

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News | 4 stories

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