NextBio

Help

interferon, gamma

Interferon-gamma (IFNG), or type II interferon, is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNG in the immune system stems in part from its ability to inhibit viral replication directly, but most importantly derives from its immunostimulatory and immunomodulatory effects. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (C...

View Gene Details



Data Correlations | 347 studies

Help for Data Correlations View All
Tissues category icon Normal tissues
Score Help
Caudate nucleus 100 100
Mesenteric lymph nod… 96 96
Spinal cord 96 96
Femur 95 95
Epidermis 95 95
Vomeronasal organ 93 93
View Top Normal tissues
Compounds category icon Compounds
Score Help
Hemagglutinins, A 100 100
Staph Enterotoxin B 89 89
Broad-spectrum Ultra… 84 84
Immunoglobulins 81 81
Concanavaline A 75 75
Hydrogen Peroxide 72 72
View Top Compounds
Diseases category icon Diseases
Score Help
Angiomyolipoma of ki… 100 100
Tuberculosis 97 97
Aplastic anemia 97 97
Acquired immunodefic… 96 96
Hepatitis C 96 96
Insulin dependent di… 94 94
View Top Diseases

Individual Studies

  • OMIM - Kidney diseases

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • NIK/NF-kappaB2 pathway in splenic DC from alymphoplasia mice

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    This study aims at identifying genes that are NIK/NF-kappaB2 responsive in murine dendritic cells matured in vivo.

    Authors: Lind F Evan, Noelle J Randolph

    Organization: Dartmouth Medical School Immunology 1 me…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving IFNG.

View All Author iconAuthors
  • Xiaoyu Hu
  • Lionel B Ivashkiv
  • Christopher B Wilson
  • John A Stamatoyannopoulos
  • Dragana Jankovic
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • National Cancer Institute (NCI)
  • Maastricht University Medical Center
  • New York University School of Medicine
  • Memorial Sloan-Kettering Cancer Center
View All Affiliations icon Organizations
  • Hospital for Special Surgery
  • University of Leuven
  • Vanderbilt University School of Medicine
  • University of California
  • National Cancer Institute

Clinical Trials | 169 trials

Help for Clinical Trials View All

Community

Help for Community
View All NextBio Users | 7 people
NextBio Groups

  • No NextBio groups were found for “IFNG”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio