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intercellular adhesion molecule 5, telencephalin

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq]

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Data Correlations | 689 studies

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Tissues category icon Normal tissues
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Dorsal striatum 100 100
Caudate nucleus 93 93
Preoptic area 93 93
Medulla oblongata 91 91
Putamen 89 89
Spinal cord 86 86
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Compounds category icon Compounds
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Pseudomonas Aerugino… 100 100
Mesatp Cpd 96 96
Butyric Acid, Sodium… 87 87
C14209 82 82
Systhane 80 80
Lonidamine 79 79
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Diseases category icon Diseases
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Heat exposure 100 100
Caloric restriction … 88 88
Bordetella 83 83
Obesity 80 80
Ewing's sarcoma of b… 80 80
Not getting enough s… 78 78
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Individual Studies

  • Lung pneumocyte cell line A549 infected with WT and deletion mutant P. aeruginosa

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    To identify the key host responses of the various parts of the bacterial type III secretion system, we utilized expression profiling of a lung pneumocytes cell line, A549, exposed to various isogenic mutant strains of Pseudomonas aeruginosa PAK.

    Authors: Ichikawa K Jeffrey, English B Sangeeta, Wolfgang C Matthew et al.

    Organization: Children's Hospital, Boston Informatics …

  • Human skeletal muscle in response to stabilized weight loss

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Six obese Caucasian premenopausal women were submitted to a weight loss program including three phases. The first one was a 4-wk very low calorie liquid formula diet, followed by 3 to 6-wk low calorie diet until reaching a loss of 10% of the initial body weight, and last a 4-wk isocaloric diet, plan…

    Authors: Clement Karine

    Organization: Hotel-Dieu Service de Medecine et Nutrit…
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Associated Researchers

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Thought leaders and organizations working on research involving ICAM5.

View All Author iconAuthors
  • Young Do Yoo
  • K Mori
  • O Carpén
  • L Tian
  • C G Gahmberg
View All Affiliations icon Organizations
  • Centro de Investigaciones Biológicas
  • Sheffield University Medical School
  • Johns Hopkins University
  • Emory University School of Medicine
  • Universidad Autónoma de Madrid

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