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heterogeneous nuclear ribonucleoprotein A1
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most...
Normal tissues
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|---|---|---|---|
| Lateral nuclear grou… |
100
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| Synovial membrane |
98
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| Substantia nigra par… |
97
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| Appendix |
97
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| Endometrium |
96
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| Penis |
95
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Compounds
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|---|---|---|---|
| Benzo[a]pyrene |
100
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| Tetradioxin |
76
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| Rosiglitazone |
68
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| Salmonella Typhi End… |
67
|
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| Triacetin |
67
|
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| Acodazole |
63
|
 Individual Studies |
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Mus musculus
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RNA Expression
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A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.
Authors: Eiichiro Noguchi, Yoichiro Homma, Xiaoyan Kang, Mihai G Netea, Xiaojing Ma
Nature immunology 2009 May -
Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production.
Authors: Tae-Don Kim, Kyung-Chul Woo, Sungchan Cho, Dae-Cheong Ha, Sung Key Jang, Kyong-Tai Kim
Genes & development 2007 Apr 1
Thought leaders and organizations working on research involving HNRNPA1.
- James L Manley
- Carlo Gambacorti-Passerini
- Christopher B Burge
- Sophie Bonnal
- Hirokazu Fukuda
- Columbia University
- Uppsala University
- Cold Spring Harbor Laboratory
- Pohang University of Science and Technology
- Massachusetts Institute of Technology
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