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heme oxygenase (decycling) 1

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq]

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Data Correlations | 1,622 studies

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Tissues category icon Normal tissues
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Femur 100 100
Pericardium 97 97
Epidermis 96 96
Fat body 91 91
Fetal organ 90 90
Set of fingers 89 89
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Compounds category icon Compounds
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Desoxycholic Acid 100 100
Cbdive_003943 96 96
Arsenic Trioxide 93 93
Nitrosyl Ion 85 85
Zinc00125862 82 82
Low density lipoprot… 80 80
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Diseases category icon Diseases
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Deficiency of oxygen… 100 100
Hemochromatosis 99 99
Lymphedema 67 67
Severe combined immu… 66 66
Helminthiasis 65 65
Infection by Candida… 65 65
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Individual Studies

  • OMIM - Specific enzyme deficiency

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Oesophagus cell line exposed to acid and bile

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The major aetiological risk factor for Barrett's oesophagus and oesophageal adenocarcinoma is gastroesophageal reflux. This study's aim was to identify genes involved in the celular response to reflux in vitro. The Barrett’s oesophagus cell line, CP-A hTERT, was exposed to media with acid, deoxych…

    Authors: Donnellan Clare, Hardie Laura

    Organization: Leeds University Molecular Epidemiology …
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Associated Researchers

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Thought leaders and organizations working on research involving HMOX1.

View All Author iconAuthors
  • Miguel P Soares
  • Wei Song
  • Hyman M Schipper
  • Hyun-Ock Pae
  • Jessy Deshane
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Medical University of Vienna
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Mayo Clinic
  • University Medical Centre Groningen
  • National Taiwan University Hospital
View All Affiliations icon Organizations
  • Instituto Gulbenkian de Ciência
  • Jagiellonian University
  • New York Medical College
  • McGill University
  • Wonkwang University School of Medicine

Clinical Trials | 11 trials

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Community

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